The Tragedy Of Macbeth Essays - Characters In Macbeth, Free Essays

Pornography Essay Example | Topics and Well Written Essays - 1000 words

Erotic entertainment - Essay Example It portrays the account of the energetic and over the top sexual issue between Kichizo Ishidaa, an inn proprietor, and Sada Abe, a whore turned hireling who works for him. By depicting the unordinary relationship and over the top love between the couple, through a few successions of sexual acts, Oshima unpretentiously reclassifies the significance of erotic entertainment and profanity. The film delineates a â€Å"extended collection of realistic sex acts† that are run of the mill of pornography motion pictures and because of rigid control laws in Japan Oshima has done all the after creation work in France (Williams 183). Numerous pundits have limited the film as explicit however a few, including the movie’s chief, guarded it in light of the fact that it drastically endeavors to broaden the conceivable outcomes of sex entertainment and difficulties the â€Å"very idea of obscenity† (183). The primary target of Oshima is by all accounts to show the crowd what they wish to see however have so far illegal themselves from survey. He further fights that when the crowd feels that all that they needed to see is â€Å"revealed† the component of â€Å"obscenity disappears† and, consequently, the specialists ought to approve the screening of obscene films (183). In her evaluate of the film, essayist and pundit Linda Williams embraces that regardless of the realistic sexual acts delineated in the film, it doesn't â€Å"negate art† (184). Individuals generally partner sex entertainment and foulness with the idea of eating up on sexual acts that individuals observe only with the end goal of fervor or as a deviatory delight. In this way, the general thought is that sex entertainment exclusively tries to inspire sensual emotions and stir the individuals who watch or read such materials. Notwithstanding, through the depiction of a solid, over the top relationship between a hireling and ace that at long last involves in envy out of posse ssiveness, Oshima pushes the limits that characterize the term sex entertainment and profanity and pull in the consideration of the crowd to new components of the term. Linda Williams ascribes the film to be â€Å"too genuine, too hard-core† yet in addition â€Å"too delightful to fathom† (184). Then again, she further notices the alarming undertone of the maiming in the movie’s peak is a befitting end, which mirrors the â€Å"Lacanian allegories† of the occasions when the film was made (184). In this way, Oshima has navigated past the ordinary domains of erotic entertainment and indecency through the delineation of the turbulent issue between the man and the lady in his film, In the Realm of Senses. A Critical Analysis of Linda William’s Definition of Obscenity: Human societies and development have advanced with the progression of time as individuals continue changing their points of view dependent on new data and information. The meaning of the w ord â€Å"obscene,† as the people see it presently, has experienced a great deal of understanding just as change before it has obtained its present measurement. In the traditionalist American culture the word vulgarity alludes to any sexual portrayal in any artistic expression that has been remembered for it essentially â€Å"for sex’s sake† without including any worth the substance; or one might say it envelops the thought of what ought to be â€Å"off (ob) the stage (scene) of representation† (Williams 165). Linda Williams in her paper titled, Second Thoughts on

Compatibility Chart for Zodiac Signs

Compatibility Chart for Zodiac Signs Relationships Print Compatibility Chart for Zodiac Signs By Arlin Cuncic Arlin Cuncic, MA, is the author of Therapy in Focus: What to Expect from CBT for Social Anxiety Disorder and 7 Weeks to Reduce Anxiety. Learn about our editorial policy Arlin Cuncic Updated on July 15, 2019 More in Relationships Spouses & Partners LGBTQ Violence and Abuse In This Article Table of Contents Expand History of Astrology Zodiac Compatibility Personality Profiles Personality Compatibility Traits That Matter Lasting Relationships View All Back To Top Zodiac compatibility charts profess to suggest ideal mates based on how well the personalities of people with the different signs align. This, of course, depends on two conditions being met: That Zodiac signs can predict personalities and that we can predict what personality types are most ideally suited. Unfortunately, for those looking for their ideal mate, neither of these conditions has been supported by research evidence. Instead, the reality is a little less dreamy and a lot more realistic. Compatibility in the sense of certain personality types being naturally better together is a fallacy. Whats more, while Zodiac signs may be a fun topic to discuss over drinks, evidence to support their usefulness in predicting personality is lacking. Illustration by  JR Bee, Verywell History of Astrology Lets first understand where the Zodiac originates from. Astrology was first used by the Babylonians to predict seasons and celestial events. In this way, for 2000 years, astrology and astronomy were viewed as the same form of science. Astrology was introduced to the Greeks in early 4th century B.C., and Plato, Aristotle, and other philosophers highly regarded it. As it was embraced by the Romans and spread to the world as a way to predict weather and other phenomena, so too were the concept of the Zodiacâ€"which first originated in Egypt. The Zodiac was based on the 12 lunar cycles required for the sun to return to its original position and 12 constellations linked to the seasons. Indeed, each Zodiac sign is linked to either Fire (Aries, Sagittarius, Leo), Water (Cancer, Scorpio, Pisces), Air (Libra, Aquarius, Gemini), or Earth (Capricorn, Taurus, Virgo). The 12 signs of the Zodiac differ from the 12 houses, which are based on the Earths daily rotation and are said to relate to relationships, finance, travel, and more. Instead, the 12 signs of the Zodiac are based on the yearlong rotation around the sun and are said to relate to character traits. An astrologer creates a persons chart based on the positions of the planets, sun, and moon at the time of birth and then interprets based on this alignment. Zodiac Compatibility If its not credible to describe compatibility in terms of Zodiac signs (in essence, in terms of when a person was born) and its not credible to describe compatibility in terms of personality traits (do opposites attract or do similarities create a bond?), how can we use the Zodiac to determine compatibility? One way to think about this is to understand that the Zodiac describes personality characteristics. The first step in this process would be to look up your sign and decide how well the description matches you. This is a bit of a  gamble  since there is no evidence to support that you will be who your sign describes you to be. If youve spent a lifetime not identifying with the description of your sign, its probably best not to base any compatibility decision on what a Zodiac compatibility chart might say. Below is a list of some of the common descriptors for the various signs. Have a look and see what you think about how well your sign describes you. Personality Profiles Aries (March 21-April 19)   Aries is the first sign of the zodiac and is described as bold, self-centered, impulsive, and independent. Aries is expected to be aggressive in a relationship and faithful if happy. Taurus (April 20-May 20) Taurus is described as practical, dependable, persistent, loyal, and possessive. In a relationship, Taurus is expected to demonstrate affection physically and may be jealous. Gemini (May 21-June 20) Gemini is described as independent, creative, and supportive. Gemini can also be unpredictable and crave change.   Cancer (June 21-July 22) Cancer is described as cautious, secretive, sensitive, complex, moody, and needy. In a relationship, Cancer is expected to be nurturing and empathetic, with a desire to please their partner. Leo (July 23-August 22) Leo is described as a faithful partner who demands loyalty. Leos can be bossy, demanding, flamboyant, outgoing, loyal, and sincere. Virgo (August 23-September 22) Virgo is described as analytical, realistic, knowledgeable, predictable, detail-oriented, and modest. In a relationship, Virgo is expected to be detached and analytical, and expect an equal partnership. They may be judgmental and not forgive easily. Libra (September 23-October 22) Libra is described as a good listener, loyal, and fair. Libra can also be resentful, spiteful, and overindulging. Libras are seen as creative, sociable, and balanced individuals. Scorpio (October 23-November 21) Scorpio is described as powerful, brooding, and magnetic. In a relationship, Scorpio is seen as adventurous and loyal. They may also be viewed as jealous and unreasonable. Sagittarius (November 22-December 21) Sagittarius is described as upbeat, loyal, open, honest, generous, and happy. In a relationship, Sagittarius may not forgive easily. Capricorn (December 22-January 19) Capricorn is described as organized, classy, serious, and practical. In a relationship, Capricorn is loyal, hardworking, but aloof and practical. Aquarius (January 20-February 18) Aquarius is described as rebellious, independent, open-minded, and honest. In a relationship, Aquarius is viewed as friendly and loving. However, they can also be unfaithful and distant. Pisces (February 19-March 20) Pisces is the last sign of the Zodiac and is described as dreamy, romantic, compassionate, and sensitive. In a relationship, Pisces is expected to be strongly devoted and to put the needs of a partner ahead of their own. Pisces can also be too sensitive. Personality Compatibility Lets say, however, that you do happen to think that the description of your sign matches you well. Whats next? Most would suggest you check what other signs are your best matches and leave it at that. Again, this presupposes that we can predict what personalities go well together, which science has yet to tell us is possible. What  does  research tell us about this issue? Instead of personality match-ups, what is most important is how well a potential partners personality matches what you perceive to be the personality of your ideal mate. This suggests that you take a moment and consider what the personality of your ideal partner would look like. Would you be looking for someone who is open, honest, caring, dependable, exciting, adventurous, and more? If youre not sure what youre looking for, have a second look at the list of descriptions above and figure out which one best describes the personality of your ideal mate. Then, when you meet a potential dating partner, consider how much they fit this profile. Traits That Matter Beyond considering what you are looking for in a partner, science tells us that compatibility does not hinge on specific personality traits. Rather, compatibility evolves out of a desire to create it. If you feel a spark of something for someone, you will likely be willing to work hard to make things work. Youll also be more likely to see the other person in a positive light and show him or her respect. In this way, the following are personality traits that matter most to compatibility, for both you and your partner: An attitude of goodwillA congenial temperamentEnthusiasm for your partnerWillingness to work through differences Lasting Relationships What are the other key ingredients to lasting relationships? Experts tell us that having similar core values is important on issues such as money and children. These are deep and lasting issues that you will need to have some agreement on in order to make things work. By the same token, enjoying the same hobbies or activities is not as important in the bigger picture. These things can change over time, and a relationship based on these shared interests alone may not survive. Finally, a lasting relationship should be built upon a sense that you are building something together or that you support each others mission in life. This goes along with the personality traits of supporting each other and building each other up. A Word From Verywell In the end, compatibility is not so much about personality, but about your relationship skills and those of your partner. These skills reflect your willingness to work on being a better person for your partner, which is related to how much you hold them in high esteem (and vice versa). Are you always looking for the best in your partner? If so, whether he or she is a Pisces or Capricorn isnt likely to matter so much. The Phases of Romantic Love

The Impact Of Industrialization On Society During The...

The Industrial Revolution Examine in detail the History of the Industrial Revolution. Discuss why Britain led the way in the Industrial Revolution and also explain in detail the effects of industrialization on society. Had it not been for the industrial revolution, I would doubt very much that we would enjoy the technology we have in the year 2000. The reason we have this technology is that between the years 1750 and 1914 a great change in the world s history was made. People started to discover faster methods of producing goods, which increased their economy. These people were mainly British and French, but after a few years the French were distracted by their revolution, and the British continued to industrialize. However you must not think this industrialization had no effects on society because it did. So in this essay I am going to talk about the history of the industrial revolution, discuss why Britain led the way in the industrial revolution and also I am going to explain to you in detail the effects of industrialization on society. In the midevel ages people were living in total darkness, and they did not know what was going on in the world around them. Happily the medieval ages were followed by the renaissance. Then came the year 1750, the year of the agricultural revolution in Britain which led away to a revolution in industry. Charles Townshend for example was one of the people who made the agricultural revolution possible. He suggested rotating theShow MoreRelatedThe Impact Of Industrialization On Society During The Industrial Revolution1721 Words   |  7 Pages Examine in detail the History of the Industrial Revolution. Discuss why Britain led the way in the Industrial Revolution and also explain in detail the effects of industrialization on society. Had it not been for the industrial revolution, I would doubt very much that we would enjoy the technology we have in the year 2000. The reason we have this technology is that between the years 1750 and 1914 a great change in the world s history was made. People started to discover faster methods of producingRead MoreSecond Industrial Revolution1000 Words   |  4 PagesSecond US Industrial Revolution, 1870 -1910 Darris Adkins Abstract In this brief paper, a description of two developments of industrialization that positively affected the United States and two developments that negatively affected the United States will be discussed. An analysis of whether or not industrialization was generally beneficial or detrimental to the lives of Americans and the history of the United States will be outlined. 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Just before the outbreak of revolutionary violence in Paris due to the consequences of industrialization, Karl Marx wrote â€Å"The Communist Manifesto.† He saw this revolutionary violence as â€Å"the opening episode of a worldwide communist revolution.†1 There was no such revolution, howeverRead MoreIndustrial Revolution Essay example1295 Words   |  6 PagesThe Industrial Revolution was a period from the 18th to the 19th century where major changes in agriculture, manufacturing and technology had a profound effect on the socioeconomic and cultural conditions of the world. The Industrial Revolution began in the United Kingdom as large deposits of coal and iron were found throughout the land which brought the rise of factories and machines, the idea then subsequently spread throughout the world. 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Britain was the best for the revolution because of their high religious tolerance, the Scientific Revolution was underway, and Britain’s government encouraged inner growth by making foreign goods more expensive. During this time period, Britain’s population grew, wealth increased, and the citizens became interested in the fate of Britain. WritingsRead Morefactors that contributed to the rise and development of sociology1511 Words   |  7 Pagesterms, sociology is the scientific study of the society and human behavior. The emergence of sociology traces back to the eighteenth century up to present day. Johnson (1998) suggests that in summary, the rise and development of sociology is based on political, economic, demographic, social and scientific changes. Ritzer (2008) asserts that the immediate cause for the beginning of sociology were political unrests especially the French Revolution that took over from the eighteenth century to theRead MoreImpact Of Industrialisation On Patterns Of Urban Development1498 Words   |  6 PagesThe impact of industrialisation on patterns of urban development in nineteenth century Europe Urbanization is defined as an omnipresent process during which a primary and rural society revolves gradually into a cultivated and industrious one. The linkage between industrialization and urban growth defies an explicit description it is tight and visible, but cannot be simply reduced to direct linearity. It is well known that many small African countries have initiated or accomplished low-level urbanizationRead MoreIndustrial Revolution Impact On Western Society1521 Words   |  7 PagesWestern society today, it is easily possible to communicate with people, travel, make purchases, and use those purchases. People can easily buy things that they need at a store, drive a car to work and to visit friends, or pick up a phone or computer to speak to friends. However, none of this would be possible without a means of communication, factories to manufacture the products, places to work, and ways to travel and transport goods. It can easily be seen that the Industrial Revolution is one The Impact Of Industrialization On Society During The... Examine in detail the History of the Industrial Revolution. Discuss why Britain led the way in the Industrial Revolution and also explain in detail the effects of industrialization on society. Had it not been for the industrial revolution, I would doubt very much that we would enjoy the technology we have in the year 2000. The reason we have this technology is that between the years 1750 and 1914 a great change in the world s history was made. People started to discover faster methods of producing goods, which increased their economy. These people were mainly British and French, but after a few years the French were distracted by their revolution, and the British continued to industrialize. However you must not think this industrialization had no effects on society because it did. So in this essay I am going to talk about the history of the industrial revolution, discuss why Britain led the way in the industrial revolution and also I am going to explain to you in detail the effects of industrialization on society. In the midevel ages people were living in total darkness, and they did not know what was going on in the world around them. Happily the medieval ages were followed by the renaissance. Then came the year 1750, the year of the agricultural revolution in Britain which led away to a revolution in industry. Charles Townshend for example was one of the people who made the agricultural revolution possible. He suggested rotating the crops every year or two, to helpShow MoreRelatedThe Impact Of Industrialization On Society During The Industrial Revolution1724 Words   |  7 PagesThe Industrial Revolution Examine in detail the History of the Industrial Revolution. Discuss why Britain led the way in the Industrial Revolution and also explain in detail the effects of industrialization on society. Had it not been for the industrial revolution, I would doubt very much that we would enjoy the technology we have in the year 2000. The reason we have this technology is that between the years 1750 and 1914 a great change in the world s history was made. People started to discoverRead MoreSecond Industrial Revolution1000 Words   |  4 PagesSecond US Industrial Revolution, 1870 -1910 Darris Adkins Abstract In this brief paper, a description of two developments of industrialization that positively affected the United States and two developments that negatively affected the United States will be discussed. An analysis of whether or not industrialization was generally beneficial or detrimental to the lives of Americans and the history of the United States will be outlined. Second US Industrial Revolution, 1870 -1910 In this briefRead MoreThe Invention Of The First Industrial Revolution1391 Words   |  6 PagesThe First Industrial Revolution Envision living in a society dominated by factories that just recently transformed from arable land and farms. Imagine constantly hearing about brand new inventions and ideas that were deemed impossible only a few years ago. Visualize working long hours in cramped factories, in exchange for low pay and contagious diseases. For some people that lived during the age of industrialization, this was their reality of life. During the 18th and 19th century, the world wasRead More How religion was affected by Industrialization Essay1368 Words   |  6 Pagesaffected by Industrialization The Communist Manifesto Great changes took place in the lives and work of people in several parts of the world, resulting from the development of the Industrial Revolution. Just before the outbreak of revolutionary violence in Paris due to the consequences of industrialization, Karl Marx wrote â€Å"The Communist Manifesto.† He saw this revolutionary violence as â€Å"the opening episode of a worldwide communist revolution.†1 There was no such revolution, howeverRead MoreIndustrial Revolution Essay example1295 Words   |  6 PagesThe Industrial Revolution was a period from the 18th to the 19th century where major changes in agriculture, manufacturing and technology had a profound effect on the socioeconomic and cultural conditions of the world. The Industrial Revolution began in the United Kingdom as large deposits of coal and iron were found throughout the land which brought the rise of factories and machines, the idea then subsequently spread throughout the world. It was perhaps on e of the greatest moments in human historyRead MoreIndustrial Revolution1160 Words   |  5 Pagesï » ¿ Industrialization of the 19th Century in America Matt Capone FIN 419 Professor Moore May 3, 2014 Over the course of time, the country of America has changed in many ways. Towards the end of the 19th century, a significant change took place in the fundamental structure of the economy. That change was industrialization. During this time period, the United States of America changed from a large, agricultural country, to an urban industrial society. The process of industrializationRead MoreSocial And Economic Impacts Of Industrial Revolution893 Words   |  4 PagesSocial and Economic Impacts of Industrial Revolution The Industrial Revolution began in the 1760’s. Britain became the first country to see its effects. Britain was the best for the revolution because of their high religious tolerance, the Scientific Revolution was underway, and Britain’s government encouraged inner growth by making foreign goods more expensive. During this time period, Britain’s population grew, wealth increased, and the citizens became interested in the fate of Britain. WritingsRead Morefactors that contributed to the rise and development of sociology1511 Words   |  7 Pagesterms, sociology is the scientific study of the society and human behavior. The emergence of sociology traces back to the eighteenth century up to present day. Johnson (1998) suggests that in summary, the rise and development of sociology is based on political, economic, demographic, social and scientific changes. Ritzer (2008) asserts that the immediate cause for the beginning of sociology were political unrests especially the French Revolution that took over from the eighteenth century to theRead MoreImpact Of Industrialisation On Patterns Of Urban Development1498 Words   |  6 PagesThe impact of industrialisation on patterns of urban development in nineteenth century Europe Urbanization is defined as an omnipresent process during which a primary and rural society revolves gradually into a cultivated and industrious one. The linkage between industrialization and urban growth defies an explicit description it is tight and visible, but cannot be simply reduced to direct linearity. It is well known that many small African countries have initiated or accomplished low-level urbanizationRead MoreIndustrial Revolution Impact On Western Society1521 Words   |  7 PagesWestern society today, it is easily possible to communicate with people, travel, make purchases, and use those purchases. People can easily buy things that they need at a store, drive a car to work and to visit friends, or pick up a phone or computer to speak to friends. However, none of this would be possible without a means of communication, factories to manufacture the products, places to work, and ways to travel and transport goods. It can easily be seen that the Industrial Revolution is one

We Were Soldiers vs. Platoon - 1075 Words

We Were Soldiers vs. Platoon After watching both of these films I noticed how combat was portrayed in the movie Platoon was different from the movie we were soldiers In the movie we were soldiers it was portrayed around several different officers it was focused on them and how they carried out their mission and how they took care of their men also they showed how on a platoon level and squad level were able to follow the battalion commander on the battlefield some example of the officers such as Lieutenant Colonel Hal Moore, Sergeant Major Basil L. Plumley EST. However you tend to lose track of the different officers such as Lt. Herrick that charged up the hill and leads his platoon after a scout and then got himself†¦show more content†¦Ahn is every bit as quick-thinking as Moore and shares his ability to anticipate the other sides actions. Pepper’s character is particularly important; he mirrors many of those in the audience as he enters bright-eyed but is quickly shocked and horrified by the carnage he witnesses first-hand and ultimately feels too overwhelmed to believe he can ever do justice to Moore and his men. It is also significant that Colonel Ahn is never demonized; we see both he and Moore praying, we see both murmuring encouragement to their wounded and weary men, and in one scene they both gaze thoughtfully up at the moon. In the movie Platoon there are three principal characters are Chris Taylor (Charlie Sheen), the young college dropout, whos the films hesitant mouthpiece, and the two sergeants who have effectively split the platoon between them. They are Barnes (Tom Berenger), a seriously out-of-control, life-sized, clay-footed version of the fighting machine Sylvester Stallone glorifies in Rambo, and Elias (Willem Dafoe), a man no less tough than Barnes, but whose tours of duty have transformed him into a soft-spoken, almost embarrassed prophet of doom. Platoon is semi-autobiographical. Stone, who served as anShow MoreRelatedThe Infantry Soldier Is The Heart Of The Fight1566 Words   |  7 PagesSustaining the Infantry Squad A White Paper MSG Jeromy White United States Army Sergeants Major Academy Class 67 SGM Johnson / Mrs. Walker 18 November 2016 Introduction: The Infantry Soldier is the heart of the fight. Sustaining the heartbeat during combat can be a tricky task. The Infantry Soldier is capable of self-sustaining for 48-72 hours; however, it comes at a price. The price is the physical toll on the Soldier’s body. With today’s modern personal protective equipment (PPE), uniformRead MoreCarrot or the Stick or Neither?894 Words   |  4 Pagesmotivate troops. In the article Why do Soldiers Fight covers nearly all of the reason troops fight. â€Å"For God and country. For self-preservation, fellow soldiers and family. For a powerfully felt cause and set of beliefs - whether just or not. For honor and glory, adventure and plunder. For money, freedom and status. To prove oneself, redeem oneself, advance a career. To follow orders or a charismatic leader. To cheat death, as in this explanation by a soldier fighting in the Middle East: I fightRead MoreThe Scientific Method Essays1678 Words   |  7 Pages â€Å"COMPARING BELIEF AND THOUGHT† EUTHTHYPHO vs. SOCRATES Saint Leo University PHI 110 Professor Anthony Nattaninia A young man by the name of Euthyphro involves himself in a conversation with the well known Socrates. During this conversation Euthyphro attempts to impose unrealistic beliefs concerning piety. Euthyphro is the plaintiff in a murder suit that he is filing against his very own father. Euthyphro believes that he has a case against his father, the reasons the youngRead MoreAir Arms Fire Was Hit By Enemy Fire1980 Words   |  8 Pages As we were ending a meeting with the local elders, my platoon was hit by enemy fire. This was the Konar River Valley. Only one road traveled north from our Combat Outpost (COP) towards the main FOB. On the east side were cliffs that would send you plummeting down towards the Konar River. The other side of the road varied between sharp cliffs to rolling hills that all inevitably jutted upward to the mountainous landscape adjacent to us. We were afforded Mine Resistant Armor Protected vehiclesRead MoreDifferences Between Internal and External Motivat ion1260 Words   |  6 PagesExtrinsic motivation – or external motivation is a misnomer. There can only be internal motivation. When you think of external motivation what we’re really talking about is influence – what we can do as part of initiative that will influence their behavior. Using such things as consensus, social proof, reciprocity; we can influence someone’s behavior. Understand, this is much different than motivation. These are psychological tricks that have an effect on behavior that isn’t so much a conscious reactionRead MoreSSD2 Module 1 Notes31223 Words   |  125 Pagessquad or platoon level, your commander or his designated representative will be the approving authority. You will prepare a draft SOP based on your review of the procedure(s), the reference source(s), and required information. Once again, make sure the SOP conveys a clear message and that it answers the questions who, what, when, and how. The next step is to submit the draft SOP for peer review and supervisory approval. Your SOP will normally be sent through squad leaders, the platoon sergeantRead MoreCommunication in the Military3236 Words   |  13 PagesCommunication has always been important with in the military from day one. Wihtout this communication no soldier would know where to be or when to be there. When the U.S. military first began we fought in a completely different style than we do today. Back then there was alot more chivalry to war to than there is today. They stood on line with their chests out proud of what they were doing. Without communication the first rank would not know when to fire their muskets, when to take a knee, when toRead MoreMalaysia Traditional Games5012 Words   |  21 Pagesconsolidated into a unique culture because almost every descent has custom forming their respective cultures. These include the likes cooperate economic activities, where the bond is strengthened and Forge Clos er with brio events and entertainment.Many games were contested because of such customs. Traditional games have been able to form a part of life experienced by the ancestors communities respectively. Important foundation that guarantees the continuity of traditional games in the past is uniformityRead MoreEssay Paper84499 Words   |  338 Pagesotherwise stated. During mobilization, the Contents proponent may modify chapters and policies contained in this regulation. Chapters 6 and 7 and appendixes E and F apply to Army National Guard Soldiers when on AD Title 10, for 30 days or more, and in all other cases, Army National Guard Soldiers are governed by NGR 600–21 and NGR 600–22. Portions of this regulation that prescribe specific conduct are punitive, and violations of these provisions may subject offenders to nonjudicial or judicialRead MoreEssay about Phd Comprehensive Exam. in Leadership15004 Words   |  61 Pagesusually sufficient but of limited value in the shifting vastness of the ocean. When it became important to precisely locate a ships position, a single point of reference was simply inadequate and sightings of multiple reference points on the shore were added to the calculation so the position of the ship could be triangulated. The more points of reference a naval pilot used to confirm their position, the more confident they could be of having a precise reading. The concept of triangulation

Coca Cola Ad Analysis Free Essays

For years, Coca-Cola has been one of the world’s leading manufacturers and distributors of soft drink beverages and other various products. Over the course of time, the company has grown tremendously and has spread many of its markets to a variety of different places. Since it first began, nobody would have thought that it would be where it is today and how big of an influence it would have on the public. We will write a custom essay sample on Coca Cola Ad Analysis or any similar topic only for you Order Now This can strongly be attributed to the company’s smart yet robust advertising and marketing policies, which have enabled it to promote its product to the consumers. In one of Coca-Cola’s advertisements, the company attempts to create a relationship between the product and consumer while displaying how the drink is a part of American culture. The idea that is being portrayed is meant to appeal to American interests by means of longstanding segments of American culture. In this advertisement, the logo at the very bottom reads, â€Å"A classic never goes out of style. † As we can see, the image of the coke bottle consists of many pictures pertaining to American history. Coke and Pepsi iframe class="wp-embedded-content" sandbox="allow-scripts" security="restricted" style="position: absolute; clip: rect(1px, 1px, 1px, 1px);" src="https://phdessay.com/coke-and-pepsi-learn-to-compete-in-india/embed/#?secret=E4eMIKjRP6" data-secret="E4eMIKjRP6" width="500" height="282" title="#8220;Coke and Pepsi#8221; #8212; Free Essays - PhDessay.com" frameborder="0" marginwidth="0" marginheight="0" scrolling="no"/iframe Regardless of whether or not a person had ever purchased a coke product, the design of the bottle immediately grasps the consumer’s attention. This is mainly due in part by the bottle’s depiction of traditional themes that people can relate to. For example, the artist who created the image included The Beatles, Marilyn Monroe, Elvis Presley, The American Flag, The Rolling Stones, Baseball, and a Cadillac, which can all be characterized as â€Å"American Classics†. Altogether, they represent some of the values that which America was built upon and what people have learned to love. Consequently, the assumption that is being made is that Coca-Cola is also an â€Å"American Classic†. It is quite clear that while the product may be considered just a drink, it is in fact more than that. By relating the beverage to some of America’s longstanding roots, the company has without a doubt created a closer relationship between product and consumer. People can view the image of the bottle and automatically be inclined to buy the product for themselves due to the sheer fact that the pictures are of such great importance to our society. Additionally, it is essential to note another subtle yet key idea that is being portrayed in the advertisement. Firstly, something that is considered to be a â€Å"classic† has to be of great significance and influence compared to other subjects in its category. While â€Å"classics† may forever be a part of our culture, the impression given by Coca-Cola is that Coke will never go out of style. How to cite Coca Cola Ad Analysis, Papers

Value of Privacy Perspectives

Privacy is a value that people in the world today hold in high esteem. Traditionally, the value of privacy was based on the strong belief that each individual deserves the right to be left alone and the right to choose what he/she wants to disclose to other people. The concept of privacy has become significantly complicated in the digital age.Advertising We will write a custom critical writing sample on Value of Privacy Perspectives specifically for you for only $16.05 $11/page Learn More People have a different understanding of what privacy is depending on factors such as their education, cultural background and even nationality. I am an international student from Kuwait and my understanding of privacy is that it is a right for everyone. The concept of value comes from the strong belief among people that each individual deserves the right to be left alone and the right to choose what to disclose to others. Various scholars have over the years written pa pers that address the issue of privacy in the digital context. The perspectives offered by various scholars relate to my understanding of privacy in some ways.  In my view, privacy has changed over the years due to the technological advances made by humans. Rule (2015) confirms that the state of privacy has changed over the past few decades and it can be expected to change even more in future. Privacy concerns have always been linked to the ability of other entities to violate the individual’s privacy. On the other hand, the extent to which a person’s privacy can be violated is linked to technology. Before the invention of technologies such as the telephone, it was hard to eavesdrop on a person’s private conversation. However, the telephone made it possible for electronic eavesdropping to occur. The prevalent use of the internet has introduced new privacy concerns. These concerns such as electronic surveillance did not exist a few decades ago when the internet was not widely used. Rule (2015) suggests that the future of privacy is very insecure as technology is introducing many privacy-destroying processes. Most people in the public acknowledge the privacy risks that the internet has introduced. Abel-Azim (2010) notes that privacy concerns are regarded as important issues as people in the Middle East adapt new technologies and make use of them. I believe that the efficiency with which computer systems and the internet can process data has increased the threats to privacy faced by individuals, especially in the developed countries that have embraced the technologies. For example, many new privacy issues have been introduced by the development and widespread use of computers and the internet.Advertising Looking for critical writing on common law? Let's see if we can help you! Get your first paper with 15% OFF Learn More Traditionally, governments and organizations relied on paper-based systems to maintain various individual r ecords. The privacy issues introduced by such systems were minimal since the information was not centralized. In the paper-based system, it was hard to compile information about a person from different sources. The digital age has made it not only possible but also easy for governments and corporations to compile vast amounts of personal information. Rule (2015) points out that various justifications have been made for collecting individual information. Some of these justifications are benign, such as that surveillance can assist enhance the health of the population. Other justifications, such as the use of the collected data to identify would-be terrorists, are repressive. A study by Abel-Azim (2010) on online privacy concerns reveals that privacy-conscious Arabs are less willing to make their personal information available in their online profiles. Digital surveillance has threatened the privacy of millions of individuals. Due to technological advances made in the past two decades , governments are able to engage in mass surveillance, Government agencies such as the National Security Agency in the US are able to monitor and analyze the telecommunications data of the entire population. Marx (2015) presents the notion that surveillance is wrongly seen to be the opposite of privacy. While privacy is seen as a good thing, surveillance is painted as a bad thing. I am one of the people who have always viewed surveillance as a dark and sinister thing. Surveillance to me meant accessing information from the public. This access is made with or without the explicit consent or desire of the individuals being surveyed. As such, surveillance is a threat to privacy, which is the value based on the right of an individual to restrict access to his/her information from others. The idea presented by Marx (2015) that surveillance might actually promote privacy is very interesting. Marx (2015) reveals that surveillance instruments such as audit trails and biometric identificatio n can be used to safeguard personal privacy. As such, surveillance is not always a negative thing in the context of privacy.  Privacy is one of the most important values in modern society. However, it has been threatened by the propagation of digital systems in recent years.Advertising We will write a custom critical writing sample on Value of Privacy Perspectives specifically for you for only $16.05 $11/page Learn More The proliferation of the internet has meant that governments, corporations, and strangers can easily gain access to an individual’s personal information. In this paper, I have compared my perspective of privacy with those of privacy scholars. There is agreement that technological advances have led to a significant erosion of privacy. I discovered an interesting perspective, which is that surveillance can serve to enhance privacy. As such, while I will be conscious of the privacy issues that the digital era brings, I will also ap preciate the positive role that surveillance plays in the society. References Abel-Azim, A.M. (2010). Online Privacy Concerns among Social Networks’ Users. Cross-Cultural Communication, 6(4), 74-89. Marx, G.T. (2015). Coming to terms; the kaleidoscope of privacy and surveillance. In B. Roessler., D. Mokrosinska (Eds.), Social Dimensions of Privacy Interdisciplinary Perspectives (pp. 32-49.). Cambridge: Cambridge University Press. Rule, J.B. (2015). Privacy: The Longue Duree. In B. Roessler., D. Mokrosinska (Eds.), Social Dimensions of Privacy Interdisciplinary Perspectives (pp. 11-31). Cambridge: Cambridge University Press. This critical writing on Value of Privacy Perspectives was written and submitted by user RoxanneSimpson to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Medical Anthropology Paper-Tay Sachs Disease Essay Example

Medical Anthropology Paper Medical Anthropology Paper-Tay Sachs Disease Paper Medical Anthropology Paper-Tay Sachs Disease Paper A normal infant has the ability to develop healthy motor functions due to the synthesis of certain enzymes vital for clearing harmful materials that can interrupt the growth process. However, babies that inherit the gene coding for Tay-Sachs disease experience motor function disorders. Tay-Sachs disease is a rare genetic disorder inherited by individuals that causes the degradation of their central nervous system. This condition is not treatable. Moreover, it progresses continuously from infancy until early childhood, a point where the patient fails to survive. The disease occurs within a defined population, commonly found among eastern European Ashkenazi Jews. The said disorder results from genetic mutations whose effects are manifested from infancy and are highly fatal for affected babies. In addition, it is acquired through genetic inheritance and is detectable prior the childs birth (Lowden 575). The disease is due to a mutation at chromosome number 15 which results in a dysfunction of the lysosomal enzyme acid hydrolase. Deficiency of Beta Hexosaminidase A is characteristic among afflicted patients. This enzymatic absence can be attributed to the occurrence of a founder effect, which accounts for the unusually high frequency of an allele that is an identical copy carried by the individual who founded the population (Slatkin 282). Currently, there are neither treatments nor drugs that would cure Tay-Sachs disease. However, studies have shown that it is possible to prevent the manifestation of Tay-Sachs among potential patients. This leads to the interests of researchers in screening for the probability of passing this disease from heterozygous parents to offspring (Lowden 575). History The disease derived its name from a British ophthalmologist named Warren Tay (1843-1927) and an American neurologist named Bernard Sachs (1858-1944). Tay first provided the characteristic description of retinal cherry-red spot in the eyes while Sachs provided the earliest descriptions of the cellular modifications occurring among afflicted patients. It was also Sachs who first concluded that this disorder is acquired through inheritance from parental genes through studies conducted among numerous patients. His research revealed that this disease notably occurs among Ashkenazi Jews of Eastern European origin (www. ntsad. org). In the year 1900, Sachs collaborated with Dr. Isadore Strauss, who then served as Mount Sinais director of pathology. Their concerted work provided additional descriptions of Tay-Sachs patients, which included observations on the diseases neuropathology. By the middle part of the 1920s decade, Mount Sinai Hospital had finally established a laboratory for neuropathological studies headed by Dr. Joseph Globus. Through this program, scientists were able to identify that autonomic neurons in bowel mucosa are involved. This was used as a diagnostic test, as direct enzymatic assays were not yet discovered. These observations were highly used in determining Tay-Sachs cases and other associated genetic disorder â€Å"through the use of morphological studies of rectal biopsies† (Desnick and Kaback 18). Succeeding years relatively added few descriptions on the morphology of Tay-Sachs disease. But with the onset of the electron microscope during the 1960s, Terry and Korey were able to find numerous bodies bounded by membranes in the cytoplasm of neurons of patients with Tay-Sachs disease. The researchers used a formalin fixed brain specimen, where the tissues were poorly preserved. But the granular bodies that they detected were consistent with brain tissues that were not previously fixed in formalin but immediately placed in a frozen state. In 1963, Terry collaborated with a researcher named Weiss and their studies revealed that the disease is characterized by these granular bodies in the neuronal cytoplasm. Their research team discovered the nature of the lipids that accumulate within neurons, microglial cells, and pericytes. According to their biochemical findings, these deposits possess a ganglioside nature (Desnick and Kaback, 22). Also during the 1960s, an enzyme assay test was developed by Kaback in order to screen heterozygous individuals carrying the allele for Tay-Sachs disease. This test was proven reliable, as it statistically demonstrates low percentage of errors and false positives. The test historically started the determination of potential genetic diseases among offspring. This is essential in preventing diseases and eventually leading to close eradication of the disease among Ashkenazi Jews. Now, it is possible to identify whether couples are at risk in having a child afflicted with the disease (Kaback 255). These efforts of Kaback, together with his team, led to the mass screening of potential disorders among individuals. This program was carefully organized and on May of 1971, approximately 18, 000 adults with Ashkenazi Jewish descent volunteered to be screened for possible heterozygosity. The said screening proved efficient and accurate in determining populations which are potentially at risk. In addition, the screening lasted and from 1969 until 1998, a total of 48,864 heterozygotes were already screened (Kaback 256). Clinical Description The degree of severity of Tay-Sachs manifestation can vary depending on the type of disease. An autosomal recessive disease, Tay-Sachs can cause â€Å"paralysis, dementia, and early death to a chronic adult form† (Genes and Disease 23). These adults afflicted by Tay-Sachs typically manifest psychosis and even neural dysfunction (Genes and Disease 23). Other manifestations of this disease include blindness and deafness early in life. Babies born with Tay-Sachs disease may develop normally during their first 3-6 months, but would eventually deteriorate mentally. They experience delay in mental progression as they experience loss of motor abilities. By the end of their first 12 months, patients rapidly regress mentally and physically. They are exposed to complications in swallowing, as well as in chest, and lung functions (Hauser 2171). Symptoms of this disease include cherry-red macular spots (see Figure 1), or a highly pronounced macular fovea centralis, and an enlarged heart. Babies with this genetic disorder experience disabled motor skills as they could poorly manage to control their heads, fail to crawl, sit and develop visual attention. They also characteristically assume a position that resembles those of frogs. Babies, supposedly at the stage of rapid development, lose their ability to maintain focus and eye contact, when Tay-Sachs starts to manifest. They also exhibit declining environmental interactions while gradually becoming unresponsive. They also develop inattention towards external stimuli until they reach a state that otherwise described vegetative. Hyperacusis, seizure, and macrocephaly are typical of Tay-Sachs disease (Kasper et al. 2318; lysosomallearning. com). There are three forms of Tay-Sachs disease. This includes the classic infantile, the juvenile form, and the adult form. Infants afflicted with Tay-Sachs do not produce Hexosaminidase A, while adults with this disease produce minimal enzymatic levels. Babies born with this disease experience both paralysis and muscle atrophy by six months of age and do not survive longer than five years. Most common ages when children manifest juvenile Tay-Sachs disease are those from 2 to 10 years old. The symptoms of patients are comparable to those with classic infantile form, but with a slower process. They develop dysarthria or speech problems, dysphagia or swallowing complications, ataxia or imbalance, and even spasticity. Patients generally die by their 15th year of age. The effects of the adult version are relatively milder than the classic infantile form, which attributes to their late onset in life. These individuals are otherwise known to possess chronic Tay-Sachs disease. Those with the adult-onset Tay-Sachs disease usually manifest symptoms by their adolescent stage, but it is also possible that these appear during childhood. Unlike babies with Tay-Sachs disease, adults with this disease do not experience blindness or deafness. Although the motor abilities are not completely degenerated, these individuals continuously experience mental weaknesses, including comprehension and memory problems. But different cases present various severity, as some can exhibit â€Å"slurred speech, muscle weakness, muscle cramps, tremors, unsteady gait and sometimes mental illness† (marchofdimes. com). Persons afflicted vary in life expectancy and some may not even to demonstrate the disease. Doctors determining the presence of this disease in individuals must consider investigating the following. Erythrocyte content of both carriers and afflicted individuals are considerably lower concentrations of sphingomyelin. Also, using the enzyme assay, serum or other cell cultures without or with less activities of Hexosaminidase A are a significant consideration. If these tests demonstrate abnormalities, then a DNA analysis must immediately be conducted. This is highly beneficial in determining other members of the family that are heterozygotes for this disorder. This has important implications in child-bearing options of couples and in diagnosing the disease prior a child’s birth. MRI are also commonly used in searching for cerebellar atrophy while electromyelogram is also used in detecting denervation and reinnvervation in individuals with adult-onset of this disease (Tidy; Zaroff 2283). Pathogenesis The most essential organelle involved in Tay-Sachs disease is the lysosome. The biogenesis of this organelle is comprised of different steps synthesizing the following: lysosomal hydrolases, membrane constitutive proteins, and new membranes. The formation of lysosomes is initiated by the fusion of trans-golgi network and late endosomes. With the acidification of vesicles in progression, trans-Golgi network vesicles develop towards maturity. This process creates a gradient that promotes the facilitation of ligand and receptor dissociation. This is highly dependent on the pH levels of the system. Here, lysosomal hydrolases are also activated (Kasper 2318). Any form of interference or abnormalities in these steps of lysosomal biogenesis could result to enzymatic impairment and lead to lysosomal storage disorder. â€Å"Following leader sequence clipping, complex oligosaccharide modification occur during transit through the Golgi, including the mannose-6-phosphate modification of high-mannose oligosaccharide chains of many soluble lysosomal hydrolases† (Kasper 2318). Using various kinds of signals, the lysosomal integral or associated membrane proteins are sorted to the membrane or interior of the lysosome. Concurrently, other processes occur such as phosphorylation, sulfation, proteolytic processing, and macromolecular assembly of heteromers. These are all very crucial steps to ensure the normal functioning of enzymes. Defects of these processes could lead to multiple enzyme or protein deficiencies (Kasper 2318). These mentioned steps are all common for lysosomal storage diseases. But the final pathway is when particular macromolecules, under normal circumstances have high flux of these substrates, within tissues and cells accumulate. When enzymatic deficiency occurs, the most common and major cause are point mutations or genetic rearrangements at a locus that encodes a single lysosomal hydrolase (Kasper 2318). These consequently result in diseases that are passed on from one generation to another. An example of lysosomal storage disorder is the Tay-Sachs disease. This complication is considered an autosomal recessive disorder that is acquired through genetic inheritance. A lysosomal acid hydrolase, ? -N-Hexosaminidase A is a heterodimer composed of alpha and beta subunits. A point mutation occurring at the ? -chain subunit results in an enzymatic deficiency of ? -N-Hexosaminidase A (Myerowitz 3955). The disorders that arise from the mutation of the alpha subunit cause the dysfunction of ? -N-Hexosaminidase A activity. This also includes the abolition of the alpha and beta isozyme activities through the action of the remaining beta subunit (see Figure 2). Tay-Sachs disease is described as one of the earliest versions of human genetic sphingolipidoses where patients suffer from the accumulation of GM2-monosialoganglioside in neurons due to the mentioned ? -N-Hexosaminidase A deficiency (Ohno and Suzuki 18563). The comparison between a healthy neuron and a neuron affected by Tay-Sachs disease is illustrated in Figure 3. The abnormality of the ? -subunit can be attributed to the major deletion found at the 5 end of the gene coding for ? -N-Hexosaminidase A ? chain. It was also discovered that in the coding sequences of ? subunits in relatively mature stages, point mutations occur that consequently result to the synthesis of unique enzymes of GM2-gangliosidosis. In cases of Ashkenazi Jews, patients were observed to possess splicing defects located at the 5 end, where intron 12 is usually donated. This splicing complication was described by employing methods such as cloning, genomic sequencing, and identification of abnormal cDNAs (Ohno and Suzuki 18563). Tay-Sachs is actually a â€Å"group of disorders† (Myerowitz 3955) with varying degree of severity and biochemical parameters. Severity ranges from mild to fatal while the parameters include â€Å"residual enzyme activity, immunoprecipitable ? -chain polypeptide, and detectable ? -chain mRNA† (Myerowitz 3955). These mentioned variations are part of differential ? -chain genetic lesions. In the case of Ashkenazi Jews, this disease has a single clinical course that leads to early childhood death and same biochemical profiles. Scientists hypothesized that the severe form of this disease is caused by a single mutation (Myerowitz 3955). It has been established that Tay-Sachs is the result of accumulation of Ganglioside GM2 due to the cells inability to degrade these granular bodies. In the absence of GM2 activator protein, â€Å" the GalNAc and NeuAc in GM2 are refractory to hexosaminidase A and sialidase respectively† (Li et al. 10014). In the study, it was found that in analyzing the conformatino of these GM2, a rigid and compact structure of the oligosaccharide head group was revealed. This is concluded to be the factor responsible for the resistance of GM2 from degradation or enzymatic hydrolysis (Li et al. 10014). All these abnormal processes are primarily attributable to mutations that occur on chromosome 15. Mutations include insertions and deletions of different base pairs, splice site mutations, point mutations, and other forms. With every modification resulting from mutation processes result in the alteration of the protein or enzymatic product, which causes the inhibition of its function. One of the most commonly observed and noted mutations are those of the Ashkenazi Jews where four base pairs are inserted in exon 11. The result is the classic infantile Tay-Sachs disease that can also be found in other ethnicities (Ohno 18563). Etiology This disease is commonly passed on from carrier parents to their offspring. Children that possess both alleles for Tay-Sachs manifest and suffer from the disease. The human body is composed of 23 pairs of chromosomes, therefore 46 chromosomes in total. These chromosomes contain genetic instructions that always come in pairs, from both maternal and paternal inheritance. But when these genes experience alterations or any form of modification, a mutation occurs and the gene loses its normal functions. Since each individual has two chromosomes, those with only one copy of the dysfunctional gene will be able to continue to function correctly as the normal gene would compensate for the impairment of the other. But if an individual acquires two recessive alleles, the individual will manifest the symptoms characteristic of the disease (Branda et al. 174; www. dnadirect. com). In cases when both parents are heterozygous for the Tay-Sachs gene, there is a 25% probability of passing the disease to the offspring, while a 50% probability of bearing a carrier individual and a 25% chance of a phenotypically and genotypically normal child (see Figure 4). In situations when only one parent is a carrier, there are 0% chances of having an afflicted child. However, they still have a 50% risk of having an offspring carrying the gene for Tay-Sachs (Branda et al. 174; www. dnadirect. com). Epidemiology Tay-Sachs disease is one of the most renowned genetic disorders associated with a certain population. This is a metabolic disorder typically acquired through genetic inheritance and occurs most frequently among Ashkenazi Jews of Eastern Europe. However, the disease is not confined within this group as it is also found among French Canadians that inhabit the South-eastern portion of Quebec and among Cajuns that live in the South-western part of Louisiana (Genes and Disease 23). One of the causes that scientists propose on the emergence of this disease is founder effect. Founder effect is a potential cause for a high frequency allele within a population in isolation. This is the case if the allele selectively remains in neutrality and if it has identical copies of the original carrier that founded the subpopulation. This is also applicable in conditions where an allele simply arose by later mutating (Slatkin 282). In explaining the phenomenon of the occurrence of high frequency alleles, experts have always employed this founder effects hypothesis. Most disease associated alleles are likely to be non-neutral. However, even alleles with mild deleterious effects could gain high levels of frequency due to founder effects. Today, another explanation is widely accepted in the scientific community in accounting for Tay-Sachs disease. This is the heterozygote advantage. This hypothesis is basically supported by the fact that most disease associated with alleles result from sphingolipid storage dysfunction. This outcome is not commonly observed in the general population. These two hypotheses were highly acknowledged prior the 1990s. But until recently, the heterozygote advantage was questioned and the founder effect has gained a relatively greater acceptance. This is due to several research studies conducted that argued in favour of founder effects as the actual cause of lipid storage diseases in the Ashkenazi Jewish population. The heterozygote advantage is unlikely as some non-lipid storage diseases (NLSDs) are due to dominant instead of recessive alleles and that these NLSDs do not benefit from the presence of disease associated alleles (Slatkin 282). The study on the debate between genetic drift and selection were further investigated by Risch et al. (p. 812). It has been established that Ashkenazi Jews have higher tendencies to acquire lysosomal storage diseases (LSDs), and in this study, four were found to occur at high frequencies. It was suggested that this condition is a result of having natural selection, otherwise termed as carrier advantage, as an impetus. The researchers compared the LSDs and NLSDs in terms of their levels of mutations, allelic frequency distribution, and mutation coalescence dates. It was found that there were no differences in the distribution nor any regular distribuion patterns were observed between LSDs and NLSDs occurring in different geographic areas. But the scientists discovered a more interesting concentration of two particular Tay-Sachs mutations in central and eastern Europe. Such an observation is an indication that genetic drift or the founder effect is the driving force that affected the population. It is the primary determinant of the genetic mutations that occur in Ashkenazi Jews (Risch et al. 812). Treatment and Screening An effective treatment or cure is currently not available for Tay-Sachs disease. Due to this, scientists are exploring on various possibilities that would enable them to formulate the appropriate treatment and management of this disease. Through intensive research projects using therapeutic approaches and clinical trials, experts have discovered a potential cure. This is by employing enzyme replacement therapy in order to compensate for the deficiency of ? -N-Hexosaminidase A absent among afflicted infants and even among adult patients. But this proposal entails several complications as it can affect the brain neurons that receive protection from the blood-brain barrier. Other current studies include gene therapy, pharmacological chaperone therapy, and neural stem cell therapy. Another alternative research is conducted on stem cell transplantation employing the blood of umbilical cord, but all these mentioned potential cure are still under the process of scientific research (www. nstad. org). These stem cell research studies investigate the potential of transplanting bone marrow in treating classic Tay-Sachs disease. These stem cells are immature cells that can differentiate into any form of cell (see Figure 5). In this case, scientists are seeking to produce blood cells from these stem cells either from a bone marrow donor or umbilical cord blood. But this remains unsuccessful in causing the reversal of brain damage that is fatal for afflicted patients. Drug options are also being explores by medical experts, which includes the miglustat drug. This has the ability to cause fatty build up reduction in the brain cells of Tay-Sachs disease patients (Escolar et al. , 2; Bembi 278; marchofdimes. com). The enzyme replacement therapy proposal is basically applicable to most lysosomal storage disorders. The objective is to perform an enzymatic replacement, a procedure comparable to that of injecting insulin to diabetics. The problem in this procedure is that HEXA enzymes are relatively too large to penetrate the blood-brain barrier. This causes the development of blood vessel junctions in the brain, which leads to neuronal cell damage. Alternate pathways were also tested such as injecting the enzyme to the cerebrospinal fluid, but this treatment is still left ineffective (www. freepatentsonline. com). As mentioned in the historical background of this disease, screening for potential carriers is very essential in preventing the manifestation of Tay-Sachs. This is very vital for populations such as Ashkenazi Jews, French Canadians, Louisiana Cajuns, and even Pennsylvania Dutch. This procedure is recommended to be conducted prior conceiving an offspring. But even after the end of an individuals childbearing years, it is still important to be screened for ones status as a carrier as it would make a tremendous difference in the lives of immediate family and close relatives (www. nstad. org). Prenatal tests are currently available such as amniocentesis and chorionic villus sampling. These tests determine the existence of the disease prior a childs birth. Typically conducted between the 15th and 20th week of pregnancy, women can choose amniocentesis where a needle is inserted to the mothers abdomen to obtain amniotic fluid samples. Fetal cells are contained within this fluid and therefore can be tested whether they possess ? -N-Hexosaminidase A. Another test usually conducted between the 10th and 12th weeks of pregnancy is CVS. This is done through the retrieval of placental cells either through tube insertion on the vagina or needle penetration through the maternal abdominal area. Again, the objective is to obtain fetal cells that would be tested for the presence of ? -N-Hexosaminidase A. If these tests reveal the absence of ? -N-Hexosaminidase A, the infant will eventually manifest the classic Tay-Sachs disease. These tests are currently being offered especially to couples who are positive for carrying the allele, and most often to those who resort to in vitro fertilization (www. marchofdimes. com). Conclusion One of the clinical considerations of this disease is that it is caused by an organelle dysfunction, particularly lysosomes. Most cells have a limited life span and therefore must be continuously replaced. Without the proper amount of lysosomal enzymes as typically attributable to a genetic disorder, the result is an abnormal accumulation of glycogen and lipids that could destroy the tissue. This case is demonstrated by Tay-Sachs disease, together with other disorders such as Gauchers disease and glycogen storage. Due to this accumulation, myelin sheaths are destroyed which would lead to the different clinical manifestations of Tay-Sachs disease. (Van de Graaff 370). The Tay-Sachs gene occurs one in every 30 Ashkenazi Jews, making almost 3% of this population as carrier of this disease. Due to lysosomal storage dysfunction, the individual becomes deficient of an enzyme called Hexosaminidase A, which codes for the metabolism of lipid molecules in cellular systems. This fatal neurodegenerative disease has an infantile form and manifests through symptoms such as macrocephaly, loss of motor skills, increased startle reaction, and a macular cherry red spot. Patients exhibiting ataxia and dementia, the juvenile-onset form of Tay-Sachs causes the death of afflicted individuals between ages 10 and 15. The adult onset of this disease is characterized by â€Å"clumsiness in childhood, progressive motor weakness in adolescence, and additional spinocerebellar, lower motor neuron symptoms, and dysarthria in adulthood† (Kasper 2318). Patients commonly demonstrate psychosis and their intelligence continuously declines. Bembi, B. â€Å"Substrate Reduction Therapy in the Infantile Form of Tay-Sachs Disease. † Neurology, 66 (2006): 278-280. Branda KJ, Tomczak J, Natowicz, MR. 2004. â€Å"Heterozygosity for Tay-Sachs and Sandhoff diseases in non-Jewish Americans with ancestry from Ireland, Great Britain, or Italy. † Genet Test 8 (2004):174-180 Desnick, R. , and Kaback, M. Tay-Sachs Disease. Ed. USA: Academic Press, 2001. â€Å"Tay Sachs Disease. † 29 January 2008 dnadirect. com/patients/tests/ashkenazi/tay_sachs. jsp. Escolar, Maria L. , Michele D. Poe, James M. Provenzale, Karen C. , Richards, M. D. , June Allison, R. N. , Susan Wood, P. N. P. , David A. Wenger, Daniel Pietryga, Donna Wall, Martin Champagne, Richard Morse, William Krivit and Joanne Kurtzberg, M. D. â€Å"Transplantation of Umbilical-Cord Blood in Babies with Infantile Krabbes Disease. † The New England Journal of Medicine, 352 (2005):2069-2081. â€Å"Compositions and method for treating lysosomal storage disease. † 30 January 2008 freepatentsonline. com/6066626. html â€Å"Cord Blood. † 4 February 2008 cordbloodusa. org/articles-a1-Cord_Blood. htm. â€Å"Genes and Disease. † Bethesda (MD): National Library of Medicine (US), NCBI. 29 January 2008 ncbi. nlm. nih. gov/books/bv. fcgi? rid=gnd. section. 238. Hauser SL, Longo DL, Harrison’s Principles of Internal Medicine. Ed. 14th ed. New York: McGraw-Hill; 1998; p. 2171. Kasper, D. L. , A. S. Fauci, D. L. Longo, E. Baraunwald, S. Hauser, S. L . Jameson, Harrison’s Principles of Internal Medicine 16th Ed. USA: McGraw-Hill Companies, Inc. 2005. Li, Y. , S. Li, , A. Hasegawa, H. Ishida, M. Kiso, A. Bernardi, P. Brocca, L. Raimondi, and S. Sonnino. â€Å"Structural basis for the resistance of Tay-Sachs Ganglioside GM2 to enzymatic degradation. † The Journal of Biological Chemistry, 274:10014-10018, 1999. Lowden, J. A. â€Å"Role of the physician in screening for carriers of Tay-Sachs disease. † CMA Journal 119 (1978):575-585. â€Å"Tay-Sachs Disease. † 29 January 2008 marchofdimes. com/professionals/14332_1227. asp. Myerowitz, R. â€Å"Splice junction mutation in some Ashkenzi Jews with Tay-Sachs disease. † Natl. Acad. Sci. USA, 85 (1998):3955-3959. â€Å"National Tay-Sachs and Allied Diseases Association. † 29 January 2008 ntsad. org/. National Eye Institute. 4 February 2008 nei. nih. gov/resources/eyegene/redeye. jpg Society for Neuroscience. 4 February 2008 sfn. org/SiteObjects/published/0000BDF20016F63800 FD712C3158BA55/0000BDF200000

Writing Contests and Competitions

Writing Contests and Competitions Writing Contests and Competitions Writing Contests and Competitions By Daniel Scocco This page will be updated regularly with the latest writing contests and competitions from around the web and the world! Make sure to bookmark it. If you are promoting a writing contest, or are aware of one that is not listed here, please send the details to info@dailywritingtips.com and well include it here as soon as possible. Last update: 08/24/2016 Upcoming Contests and Competitions Name: Atlantis Short Story Contest Prizes: $450 total, first prize is $300 Entry fee: starts from $10 Deadline: November 30, 2016 Description: Authors from all around the world are welcome to enter the one and only contest that offers a criqitue for every participating story! Name:

Decline of Myspace Annotated Bibliography Example | Topics and Well Written Essays - 500 words

Decline of Myspace - Annotated Bibliography Example The author explores the experience of the company as impacted by changing trends and tastes among target consumers which have contributed to its decline. Additionally, the effect of falling performance and impending failure has had on employees as well as how the loss of internet celebrities, such as Tila Tequila, has further depressed myspace’s outlook. Ultimately, while this article dissects the various factors contributing the companies decline in some limited detail and depth, more focus is dedicated within the article to discussing the possibility of an upcoming sale by news giant News Corp. or last ditch redesign of the site intended to revitalize the companies flailing popularity. Hudson, John. â€Å"The Decay of Myspace.† theatlanticwire.com. Jan. 12, 2011. The Atlantic Monthly Group. Web. Retrieved Nov 14 2011: http://www.theatlanticwire.com/technology/2011/01/the-decay-of-myspace/21532/ This article, initially written during the period in which facebook surpassed myspace in popularity and profits, traces the first stages of the companies decline and the efforts of News Corp. chairman Rupert Murdoch to dispel concerns over the future of the site. Revealing the facts beneath Murdoch’s optimistic pronouncements, the author explores early changes int eh marketplace and projects continued future decay of the company’s popularity following their re-organization and layoff of staff. It is made apparent in the course of the article that though even this event is characterized by spokespeople as a voluntary change, the company has begun to experience the strain of decreasing popularity. The author notes myspace’s lackadaisical performance in tech, ad and user rates, and the company’s inability to match the speed of technological evolution achieved by rival facebook. Overall, this article is a negative projection for the company’s future in light of their miscalculations in strategy

Harley Davidsons International Business Strategy Essay

Harley Davidsons International Business Strategy - Essay Example I would consider my expansion in two major countries that are attracting many other international firms; India and China. The two countries hold a lot of potential due to their massive population factor that increases the number of people who would be interested in buying the Harley Davidson Bike. The decision of Harley Davidson of not producing overseas might have some through thinking behind it but I evaluate this as a step backward by not exploring international production facilities that would surely decrease the cost of production per unit for Harley Davidson bike due to cheap labor available internationally like in countries China; Taiwan, Korea etc With International manufacturing facilities; Harley Davidson can not only take advantage of the cheap labor cost but also other aspects that affect the cost of production e.g. energy cost; Capital cost and the region’s local laws and tariffs that might facilitate Harley Davidson. Through International Manufacturing bases; Harley Davidson can also make effective measures in maintaining their inventories for the nearby target Markets. The disadvantage of Harley Davidson opening an overseas manufacturing facility can be a possible slide down of high quality that Harley Davidson has maintained with its product line as Quality standards are much hard to manage from a distance far from the central control. The movement from product to services has affected positively for the company. The sense of adventure that a Harley customer gets from the bike is well tapped by the company. Product maintenance service; after sale customer service and creating accessories other than those related to the bike itself has created a feeling of belongingness to the â€Å"Harley Owner Group†. The major competitive advantage that UPS has is the constant introduction of modern technology.

Methods For Studying Cells In The Lab :: essays research papers

Methods for studying cells in the lab Centrifugation A centrifuge is a device for separating particles from a solution according to their size, shape, density, viscosity of the medium and rotor speed. Centrifugation can be used to separate cells from one culture or to isolate an organelle from the rest of the cell. The process relies on speed; the faster and longer the particle is centrifuged, the smaller the particles are that will be separated. Separation occurs by causing the larger particles to separate to the bottom as a particle or pellet, and the smaller will remain suspended in the liquid, or supernatant. Due to smaller particles separating out first, centrifugation is often done in small steps so that the supernatant takes off all larger unwanted cells first. The basic process of centrifugation: 1) The tissue must be homogenized to allow it to separate. 2) A salt solution is added to the sample and together they are placed in the centrifuge. 3) The centrifuge is run once for every group of cellular bodies that need to be separated and the pellet is removed. 4) This supernatant is removed after each centrifuge until the time and speed that you need to remove your specific product is obtained. The last centrifuge done will remove specific products that are wanted specifically. The speed determines this, and all of the lager products must be centrifuged out first. The pellet contains what the researcher wants to study, and contains progressively smaller particles as it is separated out. The supernatant becomes progressively clearer until virtually all of the particles are removed. Density Centrifugation Although simple centrifugation removes most cell particles separately, at certain speeds particles with similar densities and particle size will all be removed at once. A different method is needed to remove these. Density centrifugation removes particles according to their density rather than their approximate size. Density centrifugation is much like normal centrifugation other than the re-suspended pellet is placed in a test tube containing at least 10 layers of glucose.

United Nations Environment Programme Environmental Sciences Essay

The United Nations Environment Programme ( UNEP ) matching United Nations environmental programme, back uping developing states in implement environmentally strongHYPERLINK â€Å" hypertext transfer protocol: //en.wikipedia.org/wiki/Environmental_peacebuilding † policies and patterns. It was start as a consequence of the United Nations Conference on the Human Environment in June 1972 and has its central offices in Nairobi, Kenya. UNEP has six regional offices and different state offices. UNEP is represent transversally the Earth by six regional offices: in Africa Nairobi, Kenya. Asia and the Pacific in Bangkok, Thailand. Europe in Geneva, Switzerland. Latin America and the Caribbean in Mexico City, Mexico. North America in Washington DC, USA, and West Asia in Manama, Bahrain. UNEP ‘s planetary and transverse scrotal position is throw back image in its organisational construction, its behavior and its human resources. UNEP staff semen from about 100 states. About tierce of UNEP ‘s about 1,000 staff reside and work in Nairobi ; the most are located around the universe in more than 28 metropoliss in 25 states. UNEP ‘s planetary foundation is in Nairobi, Kenya. It is peculiar of merely two UN programme headquartered in the underdeveloped universe. Bing base in Africa give UNEP a first-hand considerate of the environmental job expression developing states. UNEP has a caput office in Paris, France, anyplace its Division of Technology, Industry and Economics ( DTIE ) is headquartered. UNEP and DTIE have subdivisions in Geneva, Switzerland, and Osaka in Japan. UNEP ‘s chief mission is provide leading and promote partnership in helpful for the environment by animating, inform, and enable states and peoples to develop their quality of life without via media that of future coevalss. UNEP is the nominative authorization of the United Nations system in environmental impact at the planetary and regional degree. Its understanding is to organize the enlargement of environmental policy consensus by maintained the planetary environment under reappraisal and convey lifting issues to the consideration of authoritiess and the international community for action. The bid and aims of UNEP emanate from United Nations General Assembly declaration 2997 ( XXVII ) of 15 December 1972 and subsequent amendment adopted at UNCED in 1992, the Nairobi Declaration on the Role and Mandate of UNEP, adopted at the Nineteenth Session of the UNEP Governing Council, and the Malmo Ministerial Declaration of 31 May 2000. Its actions cover a big series of issues about the ambiance, Marine and tellurian ecosystems. It has play a of import portion in developing international environmental conventions, promote environmental scientific discipline and information and exemplifying the m those can work in concurrence with policy, working on the development and execution of policy with national authoritiess and regional establishment and working in concurrence with environmental Non-Governmental Organizations ( NGOs ) . UNEP has besides been lively in grant and processing environmentally related development undertakings. UNEP has aided in the development of guidelines and pacts on issues such as the international trade in potentially unsafe chemicals, Tran border air pollution, and taint of international waterways. The World Meteorological Organization and the UNEP founded the Intergovernmental Panel on Climate Change ( IPCC ) in 1988. UNEP is besides one of some Implementing Agencies for the Global Environment Facility Major maps are International agreements to better environmental protection, Periodic appraisals and scientifically sound prognosiss to keep declaration devising and international consensus on the chief environmental menaces and response to them, keep for more helpful national and international response to environmental menaces, including policy advice to authoritiess, many-sided organisations and others to beef up environmental protection and integrated environmental considerations into the sustainable development pattern, More successful coordination of environmental affair surrounded by the UN system, better consciousness and installation for environmental direction between authoritiess, the private sector and civil society, Better apprehension of the link between environment and human security, poorness obliteration, and forestalling and extenuating natural catastrophes. UNEP, s duties are Promoting international cooperation in the field of the environment and urge appropriate policies, Monitoring the significance of the planetary environment and assemblage and circulating environmental information, Catalyzing environmental consciousness and accomplishment to turn to major environmental menaces between authorities, the private sector and civil humanity, Facilitating the coordination of UN actions on affairs concerned with the environment, and guarantee, through aid, affair and engagement, that their behavior take environmental considerations into history, Developing regional programmes for environmental sustailiability. Helping, upon petition, environment ministries and other environmental governments, in peculiar in developing states and states with economic systems in passage, to explicate and implement environmental policies, Supplying country-level environmental capacity edifice and engineering support, functioning to develop international environmental jurisprudence, and supplying professional advice on the development and usage of environmental constructs and instruments. The understanding through standards-driven environmental policy in developed states over the past decennaries suggest that the authorization environmental criterions and engineerings acted as a draw on economic growing and costs have been far better than expected, while still rather low-cost given their high incomes. This realisation has induced developed states to look for more capable or at least less valuable agencies of achieve the same degree of environmental security during the usage of economic or market-based instruments. For developing states and the transitional economic systems of Eastern Europe and the old Soviet Union, the divorce of environmental policy from economic policy and from strivings to accomplish sustainable development is nonmeaningful and potentially black both economically and environmentally. Where criterions of life are intolerably low, where poorness is a major beginning and victim of environmental debasement, where natural resource direction is the engine of growing, where once designed economic systems struggle to reconstitute and retrieve, enforcing restraints on economic activity to protect the environment for its ain interest instead than as an input in sustainable development has really limited entreaty. Under these status, environmental policy can non be divorced from economic policy and development scheme. Furthermore, under conditions of speedy economic growing and huge structural alteration, mandated criterions and engineerings that permit no room for differential answe r and alteration to rapidly altering fortunes be together really valuable and hard to implement. Command-and-controls require the generous usage of assets such as capital, authorities income, direction accomplishments, administrative and enforcement capablenesss, the really factors that are in scarce supply in developing and reforming economic systems. The challenge for developing states and transitional economic systems is to categorise and follow instrument that articulation together environmental and economic policy and that are penurious in their usage of scarce development and direction resources instruments that allow differential response by economic units and adjust flexibly to altering fortunes. The hunt for instruments of environmental direction in developing states and transitional economic systems is a hunt for instruments of sustainable development. Economic instruments meet most of these conditions and are unambiguously suited for the integrating of environmental and economic policy and can be designed to progress sustainable development.

The Ethical Dilemma Of Business Ethics - 995 Words

Introduction Today, business ethics is one of the most important topics in discussion. With recent scandals come to the public of huge corporations, the public has lost its trust of businesses and require ethics be important to companies. Ethics, however, is not based solely on individual employees. In order for companies to comply with ethical standards, teamwork is necessary between the employees and the organization as a whole to create an ethical company culture that guides the actions of all members in an organization. Jacob’s Ethical Dilemma Jacob faces one of the most common ethical dilemmas—giving credit where credit is due. In fact, this dilemma is not only common in the workplace, but in every aspect of life, from school to work to volunteer organizations, and everywhere in between. Humans, in general, want to be recognized for their accomplishments. However, what about when someone is recognized unduly for an accomplishment that is not their own? While some may just go with it and enjoy the limelight they did nothing to deserve, others realize that this is not right, but what should they do about it? This is the exact dilemma Jacob was put into. Not only did Jacob’s company recognize him for an accomplishment that came mostly from Krystal’s efforts, they also gave him a $10,000 bonus for his work. From an ethical standpoint, Jacob should explain to the owners of the company that while he was the one that presented most of the material, Krystal did all of theShow Mo reRelatedBusiness Ethics, The `` Gray `` : Ethical Theories That Will Make The Decision Easier For Her Dilemma1103 Words   |  5 PagesIn business ethics, the â€Å"gray† areas are the toughest aspects that don’t have a clear right or wrong answer, but the reaction of the other party can have a potential negative impact on the business itself. Ethically, Jill will want to avoid the negative consequences as much as possible to avoid a conflict with William Potter and Henry. Objectively reviewing Henry delegated from William to Jill will have huge implications as the review moves forth. In making the decision, Jill will answer the questionRead MoreEthical Dilemmas Of A Business Leader1268 Words   |  6 PagesA business leader is seen as an influential and ethical authority figure. This ideal notion of a business leader is not always demonstrated. There are many business leaders that engage in unethical behaviors. â€Å"Ethical issues arise in every organization and throughout operations† (Collins, 2009, p. 13). Business leaders run into ethical dilemmas every day and it is up to them to make the best decision possible for the organization. Being ethical is not always easy to do in business. 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If any of these questions require illegal activity, breach of policy or personal values, break the golden rule, the action is not publicly acceptable, or would harm others - then the action is a ethical dilemma. The first criteria examines the illegality of action. The second criteria asks if the action is a violate of one’s professional or corporate ethic. The third c riteria examines the if the dilemma’s relationRead MoreEthical Issues Of Business Environment850 Words   |  4 PagesUnder present day business environment, companies can face a number of ethical issues that require making hard and often dissatisfying decisions. In this context, it is necessary to mind ethical norms as well as results of actions taken in order to keep the efficient communication across companies and keep the right balance in communication with colleagues, subordinates as well as mangers (Horton, 2015). Taking into consideration that there can be distinguished a range of ethical issues that pertain